Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

Summary: The advent of PARP inhibitors (PARPis) has profoundly changed the treatment landscape of BRCA1/BRCA2-mutated cancers. Despite this, the development of resistance to these compounds has become a major challenge. Hence, a detailed understanding of the mechanisms underlying PARPi sensitivity i...

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Dettagli Bibliografici
Autori principali: Bethany Rebekah Hill, Meryem Ozgencil, Lauryn Buckley-Benbow, Sophie Louise Pamela Skingsley, Danielle Tomlinson, Carmen Ortueta Eizmendi, Alessandro Agnarelli, Roberto Bellelli
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2024-05-01
Serie:Cell Reports
Soggetti:
CP: Molecular biology
CP: Cancer
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124724005333

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http://www.sciencedirect.com/science/article/pii/S2211124724005333

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