A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

Abstract Background Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, aff...

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Bibliographic Details
Main Authors: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li, Jiao Jiao Li
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Molecular and Cell Biology
Subjects:
Osteoarthritis
Chondrocytes
Long noncoding RNA
HOTAIR
WIF-1
Wnt/β-catenin pathway
Online Access:http://link.springer.com/article/10.1186/s12860-020-00299-6

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http://link.springer.com/article/10.1186/s12860-020-00299-6

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