Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

Profiling of circulating cell-free DNA (cfDNA) by tissue-specific base modifications, such as 5-methylcytosines (5mC), may enable the monitoring of ongoing pathophysiological processes. Nanopore sequencing allows genome-wide 5mC detection in cfDNA without bisulphite conversion. The aims of this stud...

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Bibliographic Details
Main Authors: Markus Hodal Drag, Karina Poulsdóttir Debes, Clara Sandkamm Franck, Mette Flethøj, Mille Kronborg Lyhne, Jacob Eifer Møller, Trine Pagh Ludvigsen, Thomas Jespersen, Lisbeth Høier Olsen, Tuomas O. Kilpeläinen
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Epigenetics
Subjects:
cell-free dna
methylation
epigenetics
nanopore sequencing
obesity
diagnostics
Online Access:http://dx.doi.org/10.1080/15592294.2023.2199374

Internet

http://dx.doi.org/10.1080/15592294.2023.2199374

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