1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage

1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage

Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D] and the vita...

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Bibliographic Details
Main Authors: Han Xie, Isinsu Bastepe, Wen Zhou, Birol Ay, Zara Ceraj, Ignacio A. Portales-Castillo, Eva S. Liu, Sherri-Ann M. Burnett-Bowie, Harald Jüppner, Eugene P. Rhee, Murat Bastepe, Petra Simic
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-09-01
Series:JCI Insight
Subjects:
Endocrinology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.168957

Internet

https://doi.org/10.1172/jci.insight.168957

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