Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells

In this study, 13 new hybrid compounds were synthesized starting from the natural product oleanolic acid and their in vitro cytotoxic activities were investigated on the BEAS-2B and A549 cell lines. For this purpose, initially, the secondary OH group at the C3 position of oleanolic acid was protecte...

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Bibliographic Details
Main Authors: Şenol Halil, Mercümek Berre, Şahin Rabia Büşra, Kapucu Halil Burak, Hacıosmanoğlu Ebru
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622000364