The Bacterial Amyloids Phenol Soluble Modulins from <i>Staphylococcus aureus</i> Catalyze Alpha-Synuclein Aggregation

The Bacterial Amyloids Phenol Soluble Modulins from <i>Staphylococcus aureus</i> Catalyze Alpha-Synuclein Aggregation

Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak’s seminal work redirected att...

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Bibliographic Details
Main Authors: Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E. Otzen, Sara Linse, Jia-Yi Li
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-synuclein
bacterial amyloids
aggregation
protein folding
Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/22/21/11594

Internet

https://www.mdpi.com/1422-0067/22/21/11594

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