Neuroprotective Effects of the Neural-Induced Adipose-Derived Stem Cell Secretome against Rotenone-Induced Mitochondrial and Endoplasmic Reticulum Dysfunction

Neuroprotective Effects of the Neural-Induced Adipose-Derived Stem Cell Secretome against Rotenone-Induced Mitochondrial and Endoplasmic Reticulum Dysfunction

Mesenchymal stem cells (MSCs) have therapeutic effects on neurodegenerative diseases (NDDs) known by their secreted molecules, referred to as the “secretome”. The mitochondrial complex I inhibitor, rotenone (ROT), reproduces α-synuclein (α-syn) aggregation seen in Parkinson’s disease (PD). In this p...

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Bibliographic Details
Main Authors: Mahesh Ramalingam, Sujeong Jang, Jinsu Hwang, Boeun Kim, Hyong-Ho Cho, Eungpil Kim, Han-Seong Jeong
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
rotenone
endoplasmic reticulum
mitochondria-associated membranes
mitochondrial tethering
Online Access:https://www.mdpi.com/1422-0067/24/6/5622

Internet

https://www.mdpi.com/1422-0067/24/6/5622

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