A phase I, open‐label, single‐dose study to evaluate the effect of hepatic impairment on the pharmacokinetics and safety of futibatinib

Abstract Futibatinib is a covalently binding FGFR1–4 inhibitor that received US Food and Drug Administration approval for the treatment of patients with previously treated, advanced intrahepatic cholangiocarcinoma harboring FGFR2 gene fusions/rearrangements. This phase I trial evaluated the pharmaco...

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Bibliographic Details
Main Authors: Ling Gao, Ikuo Yamamiya, Mark Pinti, Juan Carlos Rondon, Thomas Marbury, Gareth Tomlinson, Lukas Makris, Nanae Hangai, Volker Wacheck
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13585