Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies

Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies

Liquid biopsy circulating tumor DNA (ctDNA)-based approaches may represent a non-invasive means for molecular interrogation of gastrointestinal stromal tumors (GISTs). We deployed a customized 29-gene Archer® LiquidPlex™ targeted panel on 64 plasma samples from 46 patients. The majority were known t...

Full description

Bibliographic Details
Main Authors: Tun Kiat Ko, Elizabeth Lee, Cedric Chuan-Young Ng, Valerie Shiwen Yang, Mohamad Farid, Bin Tean Teh, Jason Yongsheng Chan, Nagavalli Somasundaram
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Oncology
Subjects:
liquid biopsy
imatinib
non-invasive
KIT
ctDNA (circulating tumor DNA)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.840843/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.840843/full

Similar Items