Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition.

Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition.

Subverting the host immune response to inhibit inflammation is a key virulence strategy of Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of lipid and protein mediators of inflammation. Because delayed inflammation is essential for Y. pestis to cause lethal...

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Bibliographic Details
Main Authors: Amanda Brady, Katelyn R Sheneman, Amanda R Pulsifer, Sarah L Price, Taylor M Garrison, Krishna Rao Maddipati, Sobha R Bodduluri, Jianmin Pan, Nolan L Boyd, Jing-Juan Zheng, Shesh N Rai, Jason Hellmann, Bodduluri Haribabu, Silvia M Uriarte, Matthew B Lawrenz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011280&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011280&type=printable

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