Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice

Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice

Abstract Background Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growth despite recanalization, referred to as ischemia/reperfusion injury. L...

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Bibliographic Details
Main Authors: Maximilian Bellut, Michael Bieber, Peter Kraft, Alexander N. R. Weber, Guido Stoll, Michael K. Schuhmann
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Inflammasome
NLRP3
Middle cerebral artery occlusion
Neuroinflammation
Secondary infarct growth
Online Access:https://doi.org/10.1186/s12974-022-02674-w

Internet

https://doi.org/10.1186/s12974-022-02674-w

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