Complex Formation of an RNA Aptamer with a Part of HIV-1 Tat through Induction of Base Triples in Living Human Cells Proven by In-Cell NMR

Complex Formation of an RNA Aptamer with a Part of HIV-1 Tat through Induction of Base Triples in Living Human Cells Proven by In-Cell NMR

An RNA aptamer that strongly binds to a target molecule has the potential to be a nucleic acid drug inside living human cells. To investigate and improve this potential, it is critical to elucidate the structure and interaction of RNA aptamers inside living cells. We examined an RNA aptamer for HIV-...

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Bibliographic Details
Main Authors: Omar Eladl, Yudai Yamaoki, Keiko Kondo, Takashi Nagata, Masato Katahira
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
in-cell NMR
Tat
RNA aptamer
RNA–protein interaction
functional RNA
base triple
Online Access:https://www.mdpi.com/1422-0067/24/10/9069

Internet

https://www.mdpi.com/1422-0067/24/10/9069

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