Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Abstract Background Pulmonary hypertension (PH) is a progressive and fatal cardiopulmonary disease characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance and artery pressure. Vascular remodeling is associated with the excessive cell proliferation and migration of...

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Bibliographic Details
Main Authors: Haitao Liu, Sha Zhang, Yi Liu, Jing Ma, Wei Chen, Tao Yin, Tongbin Li, Bin Liang, Ling Tao
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Respiratory Research
Subjects:
Pulmonary hypertension
Heat shock protein-110
Yes-associated protein
TEA domain transcription factor 4
Proliferation
Autophagy
Online Access:https://doi.org/10.1186/s12931-022-02124-4

Internet

https://doi.org/10.1186/s12931-022-02124-4

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