Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Abstract Background Pulmonary hypertension (PH) is a progressive and fatal cardiopulmonary disease characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance and artery pressure. Vascular remodeling is associated with the excessive cell proliferation and migration of...

Full description

Bibliographic Details
Main Authors: Haitao Liu, Sha Zhang, Yi Liu, Jing Ma, Wei Chen, Tao Yin, Tongbin Li, Bin Liang, Ling Tao
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Respiratory Research
Subjects:
Pulmonary hypertension
Heat shock protein-110
Yes-associated protein
TEA domain transcription factor 4
Proliferation
Autophagy
Online Access:https://doi.org/10.1186/s12931-022-02124-4

Similar Items

Similar Items