Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Haematopoietic stem cells rely on glycolysis for their energy demands but whether this affects their fate is unknown. Here, the authors show that forcing the cells to rely on glycolysis is important for self-renewal and that this involves a reduction in mitochondrial mass.

Detaylı Bibliyografya
Asıl Yazarlar: Nicola Vannini, Mukul Girotra, Olaia Naveiras, Gennady Nikitin, Vasco Campos, Sonja Giger, Aline Roch, Johan Auwerx, Matthias P. Lutolf
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Nature Portfolio 2016-10-01
Seri Bilgileri:Nature Communications
Online Erişim:https://doi.org/10.1038/ncomms13125

Internet

https://doi.org/10.1038/ncomms13125

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