Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy

Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy

Highlights aCD3/F/AN, anti-CD3e f(ab′)2 fragment-modified and fenofibrate-encapsulated amphiphilic nanoparticle, reprogrammed mitochondrial lipid metabolism of T cells. aCD3/F/AN specifically activated T cells in glucose-deficient conditions mimicking tumor microenvironment, and exerted an effector...

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Bibliographic Details
Main Authors: Dongyoon Kim, Yina Wu, Qiaoyun Li, Yu-Kyoung Oh
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:Nano-Micro Letters
Subjects:
Metabolic reprogramming
T cells
Fatty acid metabolism
Immunometabolic therapy
Mitochondrial function
Online Access:https://doi.org/10.1007/s40820-020-00555-6

Internet

https://doi.org/10.1007/s40820-020-00555-6

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