The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model

The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model

The hexosamine biosynthetic pathway (HBP) is essential for the production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the building block of glycosaminoglycans, thus playing a crucial role in cartilage anabolism. Although O-GlcNAcylation represents a protective regulatory mechanism in ce...

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Bibliographic Details
Main Authors: Jana Riegger, Julia Baumert, Frank Zaucke, Rolf E. Brenner
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
hexosamine biosynthetic pathway
cartilage trauma
post-traumatic osteoarthritis
chondrocytes
O-GlcNAcylation
glucosamine
Online Access:https://www.mdpi.com/1422-0067/22/14/7247

Internet

https://www.mdpi.com/1422-0067/22/14/7247

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