CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis

CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis

Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in part via the production of the proinflammatory cytokine interleukin-12. Thus, depletion of DC1 has the potential to dampen autoimmune responses. Here, we developed X-C motif chemokine...

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Bibliographic Details
Main Authors: Cody D. Moorman, Sherman Yu, Carlos G. Briseno, Hyewon Phee, Anupama Sahoo, Ambika Ramrakhiani, Ashutosh Chaudhry
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
autoimmune disease
autoimmunity
chimeric antigen receptor
CAR-T cells
CAR-Treg
type 1 conventional dendritic cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1235222/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1235222/full

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