Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives

Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives

Mono(ADP-ribose) transferases and mono(ADP-ribosyl)ating sirtuins use NAD<sup>+</sup> to perform the mono(ADP-ribosyl)ation, a simple form of post-translational modification of proteins and, in some cases, of nucleic acids. The availability of NAD<sup>+</sup> is a limiting st...

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Bibliographic Details
Main Authors: Palmiro Poltronieri, Angela Celetti, Luca Palazzo
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
ADP-ribosyl transferase (ADPRT)
Mono ADP-ribose transferases (mARTs)
cholera-toxin-like ARTs (ARTCs)
Diphtheria-toxin-like ARTs (ARTDs)
Sirtuins (Sirt)
NAD precursors
Online Access:https://www.mdpi.com/2073-4409/10/1/128

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https://www.mdpi.com/2073-4409/10/1/128

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