Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives
Mono(ADP-ribose) transferases and mono(ADP-ribosyl)ating sirtuins use NAD<sup>+</sup> to perform the mono(ADP-ribosyl)ation, a simple form of post-translational modification of proteins and, in some cases, of nucleic acids. The availability of NAD<sup>+</sup> is a limiting st...
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MDPI AG
2021-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/128 |
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| author | Palmiro Poltronieri Angela Celetti Luca Palazzo |
| author_facet | Palmiro Poltronieri Angela Celetti Luca Palazzo |
| author_sort | Palmiro Poltronieri |
| collection | DOAJ |
| description | Mono(ADP-ribose) transferases and mono(ADP-ribosyl)ating sirtuins use NAD<sup>+</sup> to perform the mono(ADP-ribosyl)ation, a simple form of post-translational modification of proteins and, in some cases, of nucleic acids. The availability of NAD<sup>+</sup> is a limiting step and an essential requisite for NAD<sup>+</sup> consuming enzymes. The synthesis and degradation of NAD<sup>+</sup>, as well as the transport of its key intermediates among cell compartments, play a vital role in the maintenance of optimal NAD<sup>+</sup> levels, which are essential for the regulation of NAD<sup>+</sup>-utilizing enzymes. In this review, we provide an overview of the current knowledge of NAD<sup>+</sup> metabolism, highlighting the functional liaison with mono(ADP-ribosyl)ating enzymes, such as the well-known ARTD10 (also named PARP10), SIRT6, and SIRT7. To this aim, we discuss the link of these enzymes with NAD<sup>+</sup> metabolism and chronic diseases, such as cancer, degenerative disorders and aging. |
| first_indexed | 2024-03-09T05:14:17Z |
| format | Article |
| id | doaj.art-b08d5ec9426342f89864e6970b9a3866 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:14:17Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b08d5ec9426342f89864e6970b9a38662023-12-03T12:46:45ZengMDPI AGCells2073-44092021-01-0110112810.3390/cells10010128Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic PerspectivesPalmiro Poltronieri0Angela Celetti1Luca Palazzo2Institute of Sciences of Food Productions, National Research Council of Italy, via Monteroni 7, 73100 Lecce, ItalyInstitute for the Experimental Endocrinology and Oncology, National Research Council of Italy, Via Sergio Pansini 5, 80131 Naples, ItalyInstitute for the Experimental Endocrinology and Oncology, National Research Council of Italy, Via Tommaso de Amicis 95, 80145 Naples, ItalyMono(ADP-ribose) transferases and mono(ADP-ribosyl)ating sirtuins use NAD<sup>+</sup> to perform the mono(ADP-ribosyl)ation, a simple form of post-translational modification of proteins and, in some cases, of nucleic acids. The availability of NAD<sup>+</sup> is a limiting step and an essential requisite for NAD<sup>+</sup> consuming enzymes. The synthesis and degradation of NAD<sup>+</sup>, as well as the transport of its key intermediates among cell compartments, play a vital role in the maintenance of optimal NAD<sup>+</sup> levels, which are essential for the regulation of NAD<sup>+</sup>-utilizing enzymes. In this review, we provide an overview of the current knowledge of NAD<sup>+</sup> metabolism, highlighting the functional liaison with mono(ADP-ribosyl)ating enzymes, such as the well-known ARTD10 (also named PARP10), SIRT6, and SIRT7. To this aim, we discuss the link of these enzymes with NAD<sup>+</sup> metabolism and chronic diseases, such as cancer, degenerative disorders and aging.https://www.mdpi.com/2073-4409/10/1/128ADP-ribosyl transferase (ADPRT)Mono ADP-ribose transferases (mARTs)cholera-toxin-like ARTs (ARTCs)Diphtheria-toxin-like ARTs (ARTDs)Sirtuins (Sirt)NAD precursors |
| spellingShingle | Palmiro Poltronieri Angela Celetti Luca Palazzo Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives Cells ADP-ribosyl transferase (ADPRT) Mono ADP-ribose transferases (mARTs) cholera-toxin-like ARTs (ARTCs) Diphtheria-toxin-like ARTs (ARTDs) Sirtuins (Sirt) NAD precursors |
| title | Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives |
| title_full | Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives |
| title_fullStr | Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives |
| title_full_unstemmed | Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives |
| title_short | Mono(ADP-ribosyl)ation Enzymes and NAD<sup>+</sup> Metabolism: A Focus on Diseases and Therapeutic Perspectives |
| title_sort | mono adp ribosyl ation enzymes and nad sup sup metabolism a focus on diseases and therapeutic perspectives |
| topic | ADP-ribosyl transferase (ADPRT) Mono ADP-ribose transferases (mARTs) cholera-toxin-like ARTs (ARTCs) Diphtheria-toxin-like ARTs (ARTDs) Sirtuins (Sirt) NAD precursors |
| url | https://www.mdpi.com/2073-4409/10/1/128 |
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