Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

Exosome is an excellent vesicle for in vivo delivery of therapeutics, including RNAi and chemical drugs. The extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without endosome trapping. However, being composed of a l...

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Bibliographic Details
Main Authors: Nasir Uddin, Daniel W. Binzel, Dan Shu, Tian-Min Fu, Peixuan Guo
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
RNA interference
RNA nanotechnology
Endolysosome trapping
Exosome engineering
Targeted delivery
Chemical drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522004865

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http://www.sciencedirect.com/science/article/pii/S2211383522004865

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