Identification of TLR2 Signalling Mechanisms Which Contribute to Barrett’s and Oesophageal Adenocarcinoma Disease Progression

Identification of TLR2 Signalling Mechanisms Which Contribute to Barrett’s and Oesophageal Adenocarcinoma Disease Progression

Chronic inflammation plays an important role in the pathogenesis of oesophageal adenocarcinoma (EAC) and its only known precursor, Barrett’s oesophagus (BE). Recent studies have shown that oesophageal TLR2 levels increase from normal epithelium towards EAC. TLR2 signalling is therefore likely to be...

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Bibliographic Details
Main Authors: Ewelina Flis, Gillian Barber, Ciara Nulty, Brian Keogh, Peter McGuirk, Akanksha Anand, Jacintha O’Sullivan, Michael Quante, Emma M. Creagh
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
oesophageal adenocarcinoma
Barrett’s oesophagus
TLR2 signalling
HMGB1
inflammation
Online Access:https://www.mdpi.com/2072-6694/13/9/2065

Internet

https://www.mdpi.com/2072-6694/13/9/2065

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