Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Objectives: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an oxidative phenotype could protect muscles from damage and ameliorate the dystrophic pathology with therapeutic relevance, but developing...

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Bibliographic Details
Main Authors: Justin P. Hardee, Karen J.B. Martins, Paula M. Miotto, James G. Ryall, Stefan M. Gehrig, Boris Reljic, Timur Naim, Jin D. Chung, Jen Trieu, Kristy Swiderski, Ashleigh M. Philp, Andrew Philp, Matthew J. Watt, David A. Stroud, Rene Koopman, Gregory R. Steinberg, Gordon S. Lynch
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
Muscular dystrophy
Muscle adaptation
Dystrophin
Utrophin
Oxidative metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302313

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http://www.sciencedirect.com/science/article/pii/S2212877820302313

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