Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

Dysfunction of the immune system and mitochondrial metabolism has been associated with Parkinson’s disease (PD) pathology. Mutations and increased kinase activity of leucine-rich repeat kinase 2 (LRRK2) are linked to both idiopathic and familial PD. However, the function of LRRK2 in the immune cells...

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Bibliographic Details
Main Authors: Asmaa Oun, Emmy Hoeksema, Ahmed Soliman, Famke Brouwer, Fabiola García-Reyes, Henderikus Pots, Marina Trombetta-Lima, Arjan Kortholt, Amalia M. Dolga
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
LRRK2
inflammation
LPS
cytokines
Online Access:https://www.mdpi.com/1422-0067/24/2/1644

Internet

https://www.mdpi.com/1422-0067/24/2/1644

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