Identifying altered developmental pathways in human globoid cell leukodystrophy iPSCs-derived NSCs using transcriptome profiling

Identifying altered developmental pathways in human globoid cell leukodystrophy iPSCs-derived NSCs using transcriptome profiling

Abstract Background Globoid cell leukodystrophy (GLD) is a devastating neurodegenerative disease characterized by widespread demyelination caused by galactocerebrosidase defects. Changes in GLD pathogenesis occurring at the molecular level have been poorly studied in human-derived neural cells. Pati...

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Bibliographic Details
Main Authors: Yafeng Lv, Yu Qin, Jing Wang, Guoshuai Tian, Wei Wang, Chunyu Cao, Ye Zhang
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Genomics
Subjects:
Galactocerebrosidase
Globoid cell leukodystrophy
Induced pluripotent stem cell
Neural stem cell
Neurodegenerative
Online Access:https://doi.org/10.1186/s12864-023-09285-6

Internet

https://doi.org/10.1186/s12864-023-09285-6

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