Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

Nuclear HMGB1 that contains 3 cysteine residues is acetylated and secreted to the extracellular space, promoting inflammation via multiple molecules such as RAGE and TLR4. We thus evaluated and characterized the redox state-dependent effects of peripheral HMGB1 on nociception. Intraplantar (i.pl.) a...

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Bibliographic Details
Main Authors: Daichi Yamasoba, Maho Tsubota, Risa Domoto, Fumiko Sekiguchi, Hiroyuki Nishikawa, Keyue Liu, Masahiro Nishibori, Hiroyasu Ishikura, Tetsushi Yamamoto, Atsushi Taga, Atsufumi Kawabata
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmacological Sciences
Subjects:
High mobility group box 1
Pain
Redox state
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000062

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http://www.sciencedirect.com/science/article/pii/S1347861316000062

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