mRNA-to-protein translation in hypoxia
Abstract Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canon...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-019-0968-4 |
| _version_ | 1818790804738539520 |
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| author | Nancy T. Chee Ines Lohse Shaun P. Brothers |
| author_facet | Nancy T. Chee Ines Lohse Shaun P. Brothers |
| author_sort | Nancy T. Chee |
| collection | DOAJ |
| description | Abstract Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathway is significantly slowed and impaired due to limited ATP availability, necessitating an alternative mechanism to mediate protein synthesis and facilitate adaptation. Hypoxia adaptation is largely mediated by hypoxia-inducible factors (HIFs). While HIFs are well known for their transcriptional functions, they also play imperative roles in translation to mediate hypoxic protein synthesis. Such adaptations to hypoxia are often hyperactive in solid tumors, contributing to the expression of cancer hallmarks, including treatment resistance. The current literature on protein synthesis in hypoxia is reviewed here, inclusive of hypoxia-specific mRNA selection to translation termination. Current HIF targeting therapies are also discussed as are the opportunities involved with targeting hypoxia specific protein synthesis pathways. |
| first_indexed | 2024-12-18T15:01:17Z |
| format | Article |
| id | doaj.art-b09c36362915423fa936bc15a22f2946 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-18T15:01:17Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-b09c36362915423fa936bc15a22f29462022-12-21T21:03:53ZengBMCMolecular Cancer1476-45982019-03-0118111310.1186/s12943-019-0968-4mRNA-to-protein translation in hypoxiaNancy T. Chee0Ines Lohse1Shaun P. Brothers2Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of MedicineDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of MedicineAbstract Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathway is significantly slowed and impaired due to limited ATP availability, necessitating an alternative mechanism to mediate protein synthesis and facilitate adaptation. Hypoxia adaptation is largely mediated by hypoxia-inducible factors (HIFs). While HIFs are well known for their transcriptional functions, they also play imperative roles in translation to mediate hypoxic protein synthesis. Such adaptations to hypoxia are often hyperactive in solid tumors, contributing to the expression of cancer hallmarks, including treatment resistance. The current literature on protein synthesis in hypoxia is reviewed here, inclusive of hypoxia-specific mRNA selection to translation termination. Current HIF targeting therapies are also discussed as are the opportunities involved with targeting hypoxia specific protein synthesis pathways.http://link.springer.com/article/10.1186/s12943-019-0968-4HypoxiamRNA-to-protein translationHIFHypoxia-inducible factorCancerHIF inhibitors |
| spellingShingle | Nancy T. Chee Ines Lohse Shaun P. Brothers mRNA-to-protein translation in hypoxia Molecular Cancer Hypoxia mRNA-to-protein translation HIF Hypoxia-inducible factor Cancer HIF inhibitors |
| title | mRNA-to-protein translation in hypoxia |
| title_full | mRNA-to-protein translation in hypoxia |
| title_fullStr | mRNA-to-protein translation in hypoxia |
| title_full_unstemmed | mRNA-to-protein translation in hypoxia |
| title_short | mRNA-to-protein translation in hypoxia |
| title_sort | mrna to protein translation in hypoxia |
| topic | Hypoxia mRNA-to-protein translation HIF Hypoxia-inducible factor Cancer HIF inhibitors |
| url | http://link.springer.com/article/10.1186/s12943-019-0968-4 |
| work_keys_str_mv | AT nancytchee mrnatoproteintranslationinhypoxia AT ineslohse mrnatoproteintranslationinhypoxia AT shaunpbrothers mrnatoproteintranslationinhypoxia |