Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels

Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels

The development of neuroprotective and repair strategies for treating progressive multiple sclerosis (MS) requires new insights into axonal injury. 4-aminopyridine (4-AP), a blocker of voltage-gated K+ (Kv) channels, is used in symptomatic treatment of progressive MS, but the underlying mechanism re...

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Bibliographic Details
Main Authors: Peter Jukkola, Yuanzheng Gu, Amy E. Lovett-Racke, Chen Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
voltage-gated K+ channel
multiple sclerosis
4-aminopyridine
experimental autoimmune encephalomyelitis
radial astroglia
brain derived neurotrophic factor
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00344/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00344/full

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