Functionalisation of Artemisinin and Its Ring-contracted Derivatives

Isoxazoline analogues of artemisinin were obtained in low yield and low diastereoselectivity from the 1,3-dipolar cycloaddition of nitrile oxides. Alternatively, starting from the aldehyde 7, a number of transformations - Wittig reaction and reduction, Henry reaction and cyanohydrin formation - were...

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Bibliographic Details
Main Authors: Wim Dehaen, Sarah Van Mierloo, Tine Van Neck
Format: Article
Language:English
Published: MDPI AG 2007-03-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/12/3/395/