Mutations Associated with Imatinib Mesylate Resistance - Review

Mutations Associated with Imatinib Mesylate Resistance - Review

Chronic myeloid leukemia (CML) arises from the fusion of the BCR and the ABL1 genes. The BCR gene (chromosome 22q11.2) and the ABL1 gene (chromosome 9q34) fuse together due to reciprocal chromosome translocation forming the Philadelphia chromosome (Ph). This fusion gene codes tyrosine kinase which a...

Full description

Bibliographic Details
Main Authors: Linev Alexandar J., Ivanov Hristo J., Zhelyazkov Ivan G., Ivanova Hristina, Goranova-Marinova Veselina S., Stoyanova Vili K.
Format: Article
Language:English
Published: Pensoft Publishers 2018-12-01
Series:Folia Medica
Subjects:
chronic myeloid leukemia
BCR-ABL
point mutation
imatinib resistance
Online Access:http://www.degruyter.com/view/j/folmed.2018.60.issue-4/folmed-2018-0030/folmed-2018-0030.xml?format=INT

Internet

http://www.degruyter.com/view/j/folmed.2018.60.issue-4/folmed-2018-0030/folmed-2018-0030.xml?format=INT

Similar Items