An N-Cyanoamide Derivative of Lithocholic Acid Co-Operates with Lysophosphatidic Acid to Promote Human Osteoblast (MG63) Differentiation

An N-Cyanoamide Derivative of Lithocholic Acid Co-Operates with Lysophosphatidic Acid to Promote Human Osteoblast (MG63) Differentiation

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty following reports that it was less calcaemic than calci...

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Bibliographic Details
Main Authors: Jason P. Mansell, Aya Tanatani, Hiroyuki Kagechika
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
osteoblasts
differentiation
lithocholic acid
alkaline phosphatase
myocardin-related transcription factor
serum response factor
Online Access:https://www.mdpi.com/2218-273X/13/7/1113

Internet

https://www.mdpi.com/2218-273X/13/7/1113

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