Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

PMOs (phosphorodiamidate morpholino oligomers) have huge potential for antisense therapy but complex and slow synthesis limits application. Here, the authors report the development of automated flow synthesis methods which reduce nucleobase coupling times from hours to minutes removing human errors...

Full description

Bibliographic Details
Main Authors: Chengxi Li, Alex J. Callahan, Mark D. Simon, Kyle A. Totaro, Alexander J. Mijalis, Kruttika-Suhas Phadke, Genwei Zhang, Nina Hartrampf, Carly K. Schissel, Ming Zhou, Hong Zong, Gunnar J. Hanson, Andrei Loas, Nicola L. B. Pohl, David E. Verhoeven, Bradley L. Pentelute
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24598-4

Internet

https://doi.org/10.1038/s41467-021-24598-4

Similar Items