Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma

Abstract The genomic instability (GI) /homologous recombination deficiency (HRD) score, calculated as the sum of the events of loss of heterozygosity (LOH), large-scale state transition (LST) and telomere allele imbalance (TAI), is used to guide the choice of treatment in several cancers, but its re...

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Bibliographic Details
Main Authors: Juan Feng, Yang Lan, Feng Liu, Ye Yuan, Jia Ge, Sen Wei, Hu Luo, Jianjun Li, Tao Luo, Xiuwu Bian
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00465-x