Engineering vanilloid-sensitivity into the rat TRPV2 channel

Engineering vanilloid-sensitivity into the rat TRPV2 channel

The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2 channel are poorly understood because selective high affinity ligands are not available, and the threshold for heat activation is extremely high (&...

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Bibliographic Details
Main Authors: Feng Zhang, Sonya M Hanson, Andres Jara-Oseguera, Dmitriy Krepkiy, Chanhyung Bae, Larry V Pearce, Peter M Blumberg, Simon Newstead, Kenton J Swartz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
capsicin
gating mechanism
temperature-sensing
thermosensing
Online Access:https://elifesciences.org/articles/16409

Internet

https://elifesciences.org/articles/16409

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