Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis

Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis

Nonalcoholic steatohepatitis (NASH) is the major cause of liver dysfunction. Animal and population studies have shown that mitochondrial aldehyde dehydrogenase (ALDH2) is implicated in fatty liver disease. However, the role of ALDH2 in NASH and the underlying mechanisms remains unclear. To address t...

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Bibliographic Details
Main Authors: Zhan-Ming Li, Chao-Yue Kong, Yu-Qin Mao, Hui-Ling Chen, Shi-Long Zhang, Jia-Ting Huang, Jin-Qing Yao, Pei-Ran Cai, Nuo Xie, Bing Han, Li-Shun Wang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Pharmacological Research
Subjects:
Non-alcoholic steatohepatitis
ALDH2
Gut microbiota
Lactobacillus
LCA
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182300258X

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http://www.sciencedirect.com/science/article/pii/S104366182300258X

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