Systematic evaluation of irinotecan-induced intestinal mucositis based on metabolomics analysis

Systematic evaluation of irinotecan-induced intestinal mucositis based on metabolomics analysis

Chemotherapy-induced intestinal mucositis (CIM) is a major dose-limiting side effect of chemotherapy, especially in regimens containing irinotecan (CPT-11). Several studies on the pathologic mechanisms of CIM focused on both the genomics and molecular pathways triggered by chemotherapy. However, sys...

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Bibliographic Details
Main Authors: Qing-Qing Yu, Heng Zhang, Shiyuan Zhao, Dadi Xie, Haibo Zhao, Weidong Chen, Min Pang, Baoqin Han, Pei Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
cancer
irinotecan
metabolomics
gas chromatography-mass spectrometry
toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.958882/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.958882/full

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