Cellular and molecular biology of sirtuins in cardiovascular disease
Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+) -dependent histone deacetylase that regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified seven mammalian homologs of the yeast SIRT silencing message regulator 2, namely, SIRT1-SIRT7. Recent in vivo and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223007217 |
| _version_ | 1797801861866061824 |
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| author | Yong-Ping Liu Ri Wen Chun-Feng Liu Tie-Ning Zhang Ni Yang |
| author_facet | Yong-Ping Liu Ri Wen Chun-Feng Liu Tie-Ning Zhang Ni Yang |
| author_sort | Yong-Ping Liu |
| collection | DOAJ |
| description | Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+) -dependent histone deacetylase that regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified seven mammalian homologs of the yeast SIRT silencing message regulator 2, namely, SIRT1-SIRT7. Recent in vivo and in vitro studies have successfully demonstrated the involvement of SIRTs in key pathways for cell biological function in physiological and pathological processes of the cardiovascular system, including processes including cellular senescence, oxidative stress, apoptosis, DNA damage, and cellular metabolism. Emerging evidence has stimulated a significant evolution in preventing and treating cardiovascular disease (CVD). Here, we review the important roles of SIRTs for the regulatory pathways involved in the pathogenesis of cardiovascular diseases and their molecular targets, including novel protein post-translational modifications of succinylation. In addition, we summarize the agonists and inhibitors currently identified to target novel specific small molecules of SIRTs. A better understanding of the role of SIRTs in the biology of CVD opens new avenues for therapeutic intervention with great potential for preventing and treating CVD. |
| first_indexed | 2024-03-13T04:56:58Z |
| format | Article |
| id | doaj.art-b0b5ba84872242148e3f1804d5a94c8a |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:58Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-b0b5ba84872242148e3f1804d5a94c8a2023-06-18T05:00:44ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114931Cellular and molecular biology of sirtuins in cardiovascular diseaseYong-Ping Liu0Ri Wen1Chun-Feng Liu2Tie-Ning Zhang3Ni Yang4Department of Pediatric, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, Liaoning 110004, ChinaDepartment of Pediatric, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, Liaoning 110004, ChinaDepartment of Pediatric, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, Liaoning 110004, ChinaCorresponding authors.; Department of Pediatric, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, Liaoning 110004, ChinaCorresponding authors.; Department of Pediatric, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, Liaoning 110004, ChinaSirtuins (SIRTs) are a nicotinic adenine dinucleotide (+) -dependent histone deacetylase that regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified seven mammalian homologs of the yeast SIRT silencing message regulator 2, namely, SIRT1-SIRT7. Recent in vivo and in vitro studies have successfully demonstrated the involvement of SIRTs in key pathways for cell biological function in physiological and pathological processes of the cardiovascular system, including processes including cellular senescence, oxidative stress, apoptosis, DNA damage, and cellular metabolism. Emerging evidence has stimulated a significant evolution in preventing and treating cardiovascular disease (CVD). Here, we review the important roles of SIRTs for the regulatory pathways involved in the pathogenesis of cardiovascular diseases and their molecular targets, including novel protein post-translational modifications of succinylation. In addition, we summarize the agonists and inhibitors currently identified to target novel specific small molecules of SIRTs. A better understanding of the role of SIRTs in the biology of CVD opens new avenues for therapeutic intervention with great potential for preventing and treating CVD.http://www.sciencedirect.com/science/article/pii/S0753332223007217SirtuinDrug discoveryMyocardial hypertrophyHeart failureIschemic reperfusionAtherosclerosis |
| spellingShingle | Yong-Ping Liu Ri Wen Chun-Feng Liu Tie-Ning Zhang Ni Yang Cellular and molecular biology of sirtuins in cardiovascular disease Biomedicine & Pharmacotherapy Sirtuin Drug discovery Myocardial hypertrophy Heart failure Ischemic reperfusion Atherosclerosis |
| title | Cellular and molecular biology of sirtuins in cardiovascular disease |
| title_full | Cellular and molecular biology of sirtuins in cardiovascular disease |
| title_fullStr | Cellular and molecular biology of sirtuins in cardiovascular disease |
| title_full_unstemmed | Cellular and molecular biology of sirtuins in cardiovascular disease |
| title_short | Cellular and molecular biology of sirtuins in cardiovascular disease |
| title_sort | cellular and molecular biology of sirtuins in cardiovascular disease |
| topic | Sirtuin Drug discovery Myocardial hypertrophy Heart failure Ischemic reperfusion Atherosclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223007217 |
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