Whole-exome sequencing study of hypospadias

Whole-exome sequencing study of hypospadias

Summary: Hypospadias results from the impaired urethral development, which is influenced by androgens, but its genetic etiology is still unknown. Through whole exome sequencing analysis, we identified NR5A1, SRD5A2, and AR as mutational hotspots in the etiology of severe hypospadias, as these genes...

Full description

Bibliographic Details
Main Authors: Zhongzhong Chen, Yunping Lei, Richard H. Finnell, Yu Ding, Zhixi Su, Yaping Wang, Hua Xie, Fang Chen
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Techniques in genetics
Human Genetics
Developmental biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300740X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422300740X

Similar Items