Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women
Two randomized placebo-controlled double-blind paralleled trials (42 men in Lyon, 19 women in Lausanne) were designed to test 2 g/day of a grape polyphenol extract during 31 days of high calorie-high fructose overfeeding. Hyperinsulinemic-euglycemic clamps and test meals with [1,1,1-13C3]-triolein w...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.854255/full |
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| author | Bérénice Segrestin Bérénice Segrestin Bérénice Segrestin Pauline Delage Angéline Nemeth Kevin Seyssel Kevin Seyssel Emmanuel Disse Emmanuel Disse Emmanuel Disse Julie-Anne Nazare Julie-Anne Nazare Stéphanie Lambert-Porcheron Laure Meiller Valerie Sauvinet Stéphanie Chanon Chantal Simon Chantal Simon Hélène Ratiney Olivier Beuf François Pralong Naba-al-Huda Yassin Alexia Boizot Mélanie Gachet Kathryn J. Burton-Pimentel Hubert Vidal Hubert Vidal Emmanuelle Meugnier Nathalie Vionnet Martine Laville Martine Laville Martine Laville |
| author_facet | Bérénice Segrestin Bérénice Segrestin Bérénice Segrestin Pauline Delage Angéline Nemeth Kevin Seyssel Kevin Seyssel Emmanuel Disse Emmanuel Disse Emmanuel Disse Julie-Anne Nazare Julie-Anne Nazare Stéphanie Lambert-Porcheron Laure Meiller Valerie Sauvinet Stéphanie Chanon Chantal Simon Chantal Simon Hélène Ratiney Olivier Beuf François Pralong Naba-al-Huda Yassin Alexia Boizot Mélanie Gachet Kathryn J. Burton-Pimentel Hubert Vidal Hubert Vidal Emmanuelle Meugnier Nathalie Vionnet Martine Laville Martine Laville Martine Laville |
| author_sort | Bérénice Segrestin |
| collection | DOAJ |
| description | Two randomized placebo-controlled double-blind paralleled trials (42 men in Lyon, 19 women in Lausanne) were designed to test 2 g/day of a grape polyphenol extract during 31 days of high calorie-high fructose overfeeding. Hyperinsulinemic-euglycemic clamps and test meals with [1,1,1-13C3]-triolein were performed before and at the end of the intervention. Changes in body composition were assessed by dual-energy X-ray absorptiometry (DEXA). Fat volumes of the abdominal region and liver fat content were determined in men only, using 3D-magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) at 3T. Adipocyte’s size was measured in subcutaneous fat biopsies. Bodyweight and fat mass increased during overfeeding, in men and in women. While whole body insulin sensitivity did not change, homeostasis model assessment of insulin resistance (HOMA-IR) and the hepatic insulin resistance index (HIR) increased during overfeeding. Liver fat increased in men. However, grape polyphenol supplementation did not modify the metabolic and anthropometric parameters or counteract the changes during overfeeding, neither in men nor in women. Polyphenol intake was associated with a reduction in adipocyte size in women femoral fat. Grape polyphenol supplementation did not counteract the moderated metabolic alterations induced by one month of high calorie-high fructose overfeeding in men and women. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov and available at https://clinicaltrials.gov/ct2/show/NCT02145780 and https://clinicaltrials.gov/ct2/show/NCT02225457. |
| first_indexed | 2024-12-12T20:44:04Z |
| format | Article |
| id | doaj.art-b0bacda2055c4fe8a62c99768623c8e6 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-12T20:44:04Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b0bacda2055c4fe8a62c99768623c8e62022-12-22T00:12:38ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.854255854255Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in WomenBérénice Segrestin0Bérénice Segrestin1Bérénice Segrestin2Pauline Delage3Angéline Nemeth4Kevin Seyssel5Kevin Seyssel6Emmanuel Disse7Emmanuel Disse8Emmanuel Disse9Julie-Anne Nazare10Julie-Anne Nazare11Stéphanie Lambert-Porcheron12Laure Meiller13Valerie Sauvinet14Stéphanie Chanon15Chantal Simon16Chantal Simon17Hélène Ratiney18Olivier Beuf19François Pralong20Naba-al-Huda Yassin21Alexia Boizot22Mélanie Gachet23Kathryn J. Burton-Pimentel24Hubert Vidal25Hubert Vidal26Emmanuelle Meugnier27Nathalie Vionnet28Martine Laville29Martine Laville30Martine Laville31INSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCentre Hospitalier Lyon-Sud Service d’Endocrinologie Diabète Nutrition Lyon, Hospices Civils de Lyon, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCNRS, INSERM, CREATIS, Université de Lyon, INSA-Lyon, Claude Bernard Lyon 1 University, UJM-Saint Etienne, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCentre Hospitalier Lyon-Sud Service d’Endocrinologie Diabète Nutrition Lyon, Hospices Civils de Lyon, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCNRS, INSERM, CREATIS, Université de Lyon, INSA-Lyon, Claude Bernard Lyon 1 University, UJM-Saint Etienne, Lyon, FranceCNRS, INSERM, CREATIS, Université de Lyon, INSA-Lyon, Claude Bernard Lyon 1 University, UJM-Saint Etienne, Lyon, FranceService of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, SwitzerlandService of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, SwitzerlandService of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, SwitzerlandService of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, SwitzerlandService of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, SwitzerlandINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceService of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, SwitzerlandINSERM, INRAe, CarMeN Laboratory, Claude Bernard Lyon 1 University, Lyon, FranceCRNH-RA, INSERM, INRAe, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceCentre Hospitalier Lyon-Sud Service d’Endocrinologie Diabète Nutrition Lyon, Hospices Civils de Lyon, Lyon, FranceTwo randomized placebo-controlled double-blind paralleled trials (42 men in Lyon, 19 women in Lausanne) were designed to test 2 g/day of a grape polyphenol extract during 31 days of high calorie-high fructose overfeeding. Hyperinsulinemic-euglycemic clamps and test meals with [1,1,1-13C3]-triolein were performed before and at the end of the intervention. Changes in body composition were assessed by dual-energy X-ray absorptiometry (DEXA). Fat volumes of the abdominal region and liver fat content were determined in men only, using 3D-magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) at 3T. Adipocyte’s size was measured in subcutaneous fat biopsies. Bodyweight and fat mass increased during overfeeding, in men and in women. While whole body insulin sensitivity did not change, homeostasis model assessment of insulin resistance (HOMA-IR) and the hepatic insulin resistance index (HIR) increased during overfeeding. Liver fat increased in men. However, grape polyphenol supplementation did not modify the metabolic and anthropometric parameters or counteract the changes during overfeeding, neither in men nor in women. Polyphenol intake was associated with a reduction in adipocyte size in women femoral fat. Grape polyphenol supplementation did not counteract the moderated metabolic alterations induced by one month of high calorie-high fructose overfeeding in men and women. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov and available at https://clinicaltrials.gov/ct2/show/NCT02145780 and https://clinicaltrials.gov/ct2/show/NCT02225457.https://www.frontiersin.org/articles/10.3389/fnut.2022.854255/fullpolyphenolsoverfeedinginsulin sensitivitynutritional interventioninsulin resistancegrape polyphenols |
| spellingShingle | Bérénice Segrestin Bérénice Segrestin Bérénice Segrestin Pauline Delage Angéline Nemeth Kevin Seyssel Kevin Seyssel Emmanuel Disse Emmanuel Disse Emmanuel Disse Julie-Anne Nazare Julie-Anne Nazare Stéphanie Lambert-Porcheron Laure Meiller Valerie Sauvinet Stéphanie Chanon Chantal Simon Chantal Simon Hélène Ratiney Olivier Beuf François Pralong Naba-al-Huda Yassin Alexia Boizot Mélanie Gachet Kathryn J. Burton-Pimentel Hubert Vidal Hubert Vidal Emmanuelle Meugnier Nathalie Vionnet Martine Laville Martine Laville Martine Laville Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women Frontiers in Nutrition polyphenols overfeeding insulin sensitivity nutritional intervention insulin resistance grape polyphenols |
| title | Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women |
| title_full | Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women |
| title_fullStr | Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women |
| title_full_unstemmed | Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women |
| title_short | Polyphenol Supplementation Did Not Affect Insulin Sensitivity and Fat Deposition During One-Month Overfeeding in Randomized Placebo-Controlled Trials in Men and in Women |
| title_sort | polyphenol supplementation did not affect insulin sensitivity and fat deposition during one month overfeeding in randomized placebo controlled trials in men and in women |
| topic | polyphenols overfeeding insulin sensitivity nutritional intervention insulin resistance grape polyphenols |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.854255/full |
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