The human insula processes both modality-independent and pain-selective learning signals.

Prediction errors (PEs) are generated when there are differences between an expected and an actual event or sensory input. The insula is a key brain region involved in pain processing, and studies have shown that the insula encodes the magnitude of an unexpected outcome (unsigned PEs). In addition t...

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Bibliographic Details
Main Authors: Björn Horing, Christian Büchel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001540