Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects

Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects

BackgroundCholinergic drugs are the most commonly used drugs for the treatment of Alzheimer’s disease (AD). Therefore, a better understanding of the cholinergic system and its relation to both AD-related biomarkers and cognitive functions is of high importance.ObjectivesTo evaluate the relationships...

Full description

Bibliographic Details
Main Authors:	Unnur D. Teitsdottir, Taher Darreh-Shori, Sigrun H. Lund, Maria K. Jonsdottir, Jon Snaedal, Petur H. Petersen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Aging Neuroscience
Subjects:	Alzheimer’s disease cerebrospinal fluid acetylcholinesterase butyrylcholinesterase cholinergic system inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.876019/full

Similar Items

Predicted overlapping microRNA regulators of acetylcholine packaging and degradation in neuroinflammation-related disorders
by: Bettina eNadorp, et al.
Published: (2014-02-01)

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
by: Roger M. Lane, et al.
Published: (2024-04-01)

Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase
by: Anne Loesche, et al.
Published: (2019-03-01)

Central Cholinergic Nervous System and Cholinergic Agents
by: Jiří Patočka
Published: (1998-01-01)

Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs
by: Haya Hussain, et al.
Published: (2022-04-01)

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease
by: Katarina Komatović, et al.
Published: (2022-06-01)

Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
by: Kaitlyn N. Alcorn, et al.
Published: (2024-12-01)

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies
by: Raquel B. M. de Almeida, et al.
Published: (2023-01-01)

Anticholinesterase Activity and Bioactive Compound Profiling of Six Hop (<i>Humulus lupulus</i> L.) Varieties
by: Bartłomiej Sagan, et al.
Published: (2024-12-01)

The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke
by: Lara Caeiro, et al.
Published: (2021-01-01)

Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase
by: Wang Yue-Hu, et al.
Published: (2012-09-01)

Resorcinol-, catechol- and saligenin-based bronchodilating β2-agonists as inhibitors of human cholinesterase activity
by: Anita Bosak, et al.
Published: (2017-01-01)

Cholinergic Stress Signals Accompany MicroRNA-Associated Stereotypic Behavior and Glutamatergic Neuromodulation in the Prefrontal Cortex
by: Gilli Moshitzky, et al.
Published: (2020-06-01)

Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study
by: Xu Lin, et al.
Published: (2020-09-01)

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer’s-like Tauopathy Mouse Model
by: Maciej Zadrozny, et al.
Published: (2024-04-01)

Synthesis and anti-Alzheimer activity of new N-(5, 6-dimethyl-1H-benzo[d] imidazol-2-yl)-1-phenylmethanimine derivatives
by: Hiba Ali Hasan, et al.
Published: (2024-10-01)

Synthesis, biological investigation, and docking studies of benzimidazole derivatives as butyrylcholinesterase and acetylcholinesterase inhibitors
by: Maryam Rouhi, et al.
Published: (2024-06-01)

A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease
by: Sultan Darvesh, et al.
Published: (2023-12-01)

Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: In silico and in vitro approaches
by: Morteza Sadeghi, et al.
Published: (2024-01-01)

ANTICHOLINESTERASE AND ANTIOXIDANT ACTIVITIES OF COMMERCIAL PREPARATIONS FROM Ginkgo biloba LEAVES
by: Dominik Szwajgier, et al.
Published: (2013-10-01)

Identification of Indazole-Based Thiadiazole-Bearing Thiazolidinone Hybrid Derivatives: Theoretical and Computational Approaches to Develop Promising Anti-Alzheimer’s Candidates
by: Yousaf Khan, et al.
Published: (2023-11-01)

Anticholinesterase Activities of Different Solvent Extracts of Brewer’s Spent Grain
by: Rares I. Birsan, et al.
Published: (2021-04-01)

Assessment of Physicochemical Quality, Antioxidant Content and Activity, and Inhibition of Cholinesterase between Unripe and Ripe Blueberry Fruit
by: Hyesung Hwang, et al.
Published: (2020-05-01)

Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease
by: Muslum Gok, et al.
Published: (2022-09-01)

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study
by: Bushra Adalat, et al.
Published: (2023-01-01)

Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T Leukemia
by: Oxana Dobrovinskaya, et al.
Published: (2016-08-01)

Derivatives of Amodiaquine as Potent Human Cholinesterases Inhibitors: Implication for Treatment of Alzheimer’s Disease
by: Ana Matošević, et al.
Published: (2024-11-01)

Vanillin derivatives as antiamnesic agents in scopolamine-induced memory impairment in mice
by: Qamar Gul, et al.
Published: (2024-02-01)

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-Aspartate Receptor Antagonists
by: Jan Konecny, et al.
Published: (2020-12-01)

Extraction of Antioxidants from Winemaking Byproducts: Effect of the Solvent on Phenolic Composition, Antioxidant and Anti-Cholinesterase Activities, and Electrochemical Behaviour
by: María José Jara-Palacios, et al.
Published: (2020-07-01)

Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays
by: Carlos Martins-Gomes, et al.
Published: (2022-08-01)

Cholinesterases Inhibition, Anticancer and Antioxidant Activity of Novel Benzoxazole and Naphthoxazole Analogs
by: Alicja Skrzypek, et al.
Published: (2022-12-01)

Microwave Assisted Synthesis of BenzilideneBenzylamine and Its Acetylcholinesterase and Butyrylcholinesterase Activity
by: Himayat Ullah, et al.
Published: (2020-12-01)

Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches
by: Ifeoma Felicia Chukwuma, et al.
Published: (2023-09-01)

Anticholinesterase activities from aqueous extract of different plant parts of Erica manipuliflora
by: Çiğdem Kuş, et al.
Published: (2017-12-01)

Association between cholinesterase activity and critical illness brain dysfunction
by: Christopher G. Hughes, et al.
Published: (2022-12-01)

Neuroprotective Effects of Blueberries through Inhibition on Cholinesterase, Tyrosinase, Cyclooxygenase-2, and Amyloidogenesis
by: Pari Samani, et al.
Published: (2023-01-01)

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
by: Keith D. Green, et al.
Published: (2018-12-01)

Anticholinesterase activity of selected phenolic acids and flavonoids – interaction testing in model solutions
by: Dominik Szwajgier
Published: (2015-12-01)

Acetylcholinesterase: Old Questions and New Developments
by: Karl eTsim, et al.
Published: (2013-01-01)