Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG<sub>1000</sub>]-<i>b</i>-[PLLA] Multi-Block Copolymers in Healthy Horse Joints

Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG<sub>1000</sub>]-<i>b</i>-[PLLA] Multi-Block Copolymers in Healthy Horse Joints

There is an increasing interest in controlled release systems for local therapy in the treatment of human and equine joint diseases, aiming for optimal intra-articular concentrations with no systemic side effects. In this study, the intra-articular tolerability and suitability for local and sustaine...

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Bibliographic Details
Main Authors: Stefan M. Cokelaere, Wilhelmina M.G.A.C. Groen, Saskia G.M. Plomp, Janny C. de Grauw, Paul M. van Midwoud, Harrie H. Weinans, Chris H.A. van de Lest, Marianna A. Tryfonidou, P. René van Weeren, Nicoline M. Korthagen
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
tacrolimus
prolonged-action preparation
equine
arthritis
biomarkers
synovial fluid
Online Access:https://www.mdpi.com/1999-4923/13/9/1438

Internet

https://www.mdpi.com/1999-4923/13/9/1438

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