Decreased Thymic Output Contributes to Immune Defects in Septic Patients

Background: Prolonged immunosuppression and hypoinflammation, termed compensatory anti-inflammatory response syndrome (CARS), contribute to high morbidity and mortality in the late phase of sepsis. Although apoptosis is a well-known cause of lymphopenia in sepsis, the contribution of thymic output t...

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Bibliographic Details
Main Authors: Natascha Sommer, Steffen Noack, Andreas Hecker, Holger Hackstein, Gregor Bein, Norbert Weissmann, Werner Seeger, Konstantin Mayer, Matthias Hecker
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/9/9/2695