Increasing Endoglin Deletion in Endothelial Cells Exacerbates the Severity of Brain Arteriovenous Malformation in Mouse

Increasing Endoglin Deletion in Endothelial Cells Exacerbates the Severity of Brain Arteriovenous Malformation in Mouse

Endoglin (<i>ENG</i>) mutation causes type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have arteriovenous malformations (AVMs) in multiple organs, including the brain. In mice, <i>Eng</i> deletion induced by R26RCreER or SM22αCre leads to AVM development in...

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Bibliographic Details
Main Authors: Zahra Shabani, Leandro Barbosa Do Prado, Rui Zhang, Wan Zhu, Sonali S. Shaligram, Alka Yadav, Calvin Wang, Hua Su
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Biomedicines
Subjects:
arteriovenous malformations
endothelial cells
endoglin
hereditary hemorrhagic telangiectasia
Online Access:https://www.mdpi.com/2227-9059/12/8/1691

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https://www.mdpi.com/2227-9059/12/8/1691

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