Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

A mucosal infectious disease episode can render the host either more or less susceptible to recurrent infection, but the specific mechanisms that tip the balance remain unclear. We investigated this question in a mouse model of recurrent urinary tract infection and found that a prior bladder infecti...

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Bibliographic Details
Main Authors: Lu Yu, Valerie P O'Brien, Jonathan Livny, Denise Dorsey, Nirmalya Bandyopadhyay, Marco Colonna, Michael G Caparon, Elisha DO Roberson, Scott J Hultgren, Thomas J Hannan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
mucosal infection
recurrent infection
mucosal remodeling
uropathogenic E. coli
tumor necrosis factor alpha
urinary tract infection
Online Access:https://elifesciences.org/articles/46677

Internet

https://elifesciences.org/articles/46677

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