Oral Bioavailability Enhancement of Vancomycin Hydrochloride with Cationic Nanocarrier (Leciplex): Optimization, In Vitro, Ex Vivo, and In Vivo Studies

Oral Bioavailability Enhancement of Vancomycin Hydrochloride with Cationic Nanocarrier (Leciplex): Optimization, In Vitro, Ex Vivo, and In Vivo Studies

To explore the performance of the cationic nanocarrier leciplex (LPX) in escalating the oral bioavailability of vancomycin hydrochloride (VAN) by promoting its intestinal permeability. With the aid of a D-optimal design, the effect of numerous factors, including lipid molar ratio, cationic surfactan...

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Bibliographic Details
Main Authors: Menna M. Abdellatif, Sara Mohamed Ahmed, Mohamed A. El-Nabarawi, Mahmoud Teaima
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Scientia Pharmaceutica
Subjects:
cationic nanocarriers
oral bioavailability
vancomycin hydrochloride
intestinal permeability
leciplex
BCS class III
Online Access:https://www.mdpi.com/2218-0532/91/1/1

Internet

https://www.mdpi.com/2218-0532/91/1/1

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