Polymeric epitope-based vaccine induces protective immunity against group A Streptococcus

Abstract Group A Streptococcus (Strep A) is a life-threatening human pathogen with no licensed vaccine. Here, we used a biopolymer particle (BP) approach to display repeats of Strep A vaccine candidate peptides p*17 and K4S2 derived from M and non-M protein, respectively. BPs densely displaying both...

Full description

Bibliographic Details
Main Authors: Shuxiong Chen, Victoria Ozberk, Gayathri Sam, Zennia Jean C. Gonzaga, Ainslie Calcutt, Manisha Pandey, Michael F. Good, Bernd H. A. Rehm
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00695-x