Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens

Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens

Early T stage colorectal cancers (CRC) that invade lymph nodes (Stage IIIA) are rare and greatly under-represented in large-scale genomic mapping projects. We retrieved 10 Stage IIIA CRC cases, matched these to 16 Stage 1 CRC cases (T1 depth without lymph node metastasis) and carried out deep sequen...

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Bibliographic Details
Main Authors: Jun Li, Pascal Steffen, Benita C. Y. Tse, Mahsa S. Ahadi, Anthony J. Gill, Alexander F. Engel, Mark P. Molloy
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
colorectal cancer
tumour mutation burden
homologous recombination repair
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Online Access:https://www.mdpi.com/2072-6694/14/12/2933

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https://www.mdpi.com/2072-6694/14/12/2933

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