Li–Fraumeni syndrome in Tunisian carriers with different and rare tumor phenotype: genotype–phenotype correlation

Li–Fraumeni syndrome in Tunisian carriers with different and rare tumor phenotype: genotype–phenotype correlation

Abstract Background Li–Fraumeni syndrome (LFS) is a rare autosomal hereditary predisposition to multiples cancers, mainly affecting young individuals. It is characterized by a broad tumor spectrum. To our best knowledge, only one Tunisian study with a confirmed LFS was published. Methods Our study f...

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Bibliographic Details
Main Authors: Hela Sassi, Rym Meddeb, Mohamed Aziz Cherif, Chiraz Nasr, Aouatef Riahi, Samia Hannachi, Neila Belguith, Ridha M’rad
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Medical Genomics
Subjects:
Li–Fraumeni syndrome
TP53 germline variants
Breast cancer
Phyllode tumor
Intralobular breast carcinoma
Osteosarcoma
Online Access:https://doi.org/10.1186/s12920-022-01189-w

Internet

https://doi.org/10.1186/s12920-022-01189-w

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