Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations

Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations

The pathological growth of amyloid fibrils in neurons underlies the progression of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. Fibrils form when soluble monomers oligomerise in the cytoplasm. Their subsequent growth occurs via nucleated polymerization mechanisms involvi...

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Bibliographic Details
Main Authors: Julian C. Shillcock, Janna Hastings, Nathan Riguet, Hilal A. Lashuel
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Amyloid
Fluorescent proteins
Secondary nucleation
Aggregation
Inclusion formation
Coarse-grained simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021005262

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http://www.sciencedirect.com/science/article/pii/S2001037021005262

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